Associations between misfolded alpha-synuclein aggregates and Alzheimer's disease pathology in vivo.

ABSTRACT:

Introduction

We examined the relations of misfolded alpha synuclein (α-synuclein) with Alzheimer's disease (AD) biomarkers in two large independent cohorts.

Methods

We included Biomarkers for Identifying Neurodegenerative Disorders Early and Reliably Two (BioFINDER-2) and Alzheimer's Disease Neuroimaging Initiative (ADNI) participants (n = 2315, cognitively unimpaired, mild cognitive impairment, AD dementia) who had cross-sectional cerebrospinal fluid (CSF) α-synuclein measurement from seed-amplification assay as well as cross-sectional and longitudinal amyloid beta (Aβ) and tau levels (measured in CSF and/or by positron emission tomography). All analyses were adjusted for age, sex, and cognitive status.

Results

Across cohorts, the main biomarker associated with α-syn

SUBMITTER: Pichet Binette A 

PROVIDER: S-EPMC11567871 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature