TRIM47 is a prognostic biomarker for gallbladder cancer and promotes tumor progression through regulating K63-linked ubiquitination of PARP1.

ABSTRACT:

Background

Gallbladder cancer (GBC) is one of the most lethal malignancies worldwide with an extremely poor prognosis. Previous studies have suggested that tripartite motif containing 47 (TRIM47) is involved in the progression of numerous cancers. However, the molecular mechanism and function of TRIM47 in GBC remain unclear.

Methods

The clinical significance of TRIM47 was evaluated using immunohistochemistry. Functional assays were performed in vitro and in vivo to determine the role of TRIM47 in GBC. Mass spectrometric analysis, western blotting, and immunoprecipitation assays were performed to investigate the molecular mechanisms involved.

Results

In this study, TRIM47 was upregulated in GBC tissues and associated with shorter overall survival rates and TRIM47 was i

SUBMITTER: Xu M 

PROVIDER: S-EPMC11567951 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature