In silico study, synthesis and antimalarial evaluation of hybrid pyridine substituted pyrazole 1,3,5-triazine derivatives.

ABSTRACT: Malaria is a significant global public health issue, particularly prevalent in Africa, Asia, and Latin America, necessitating urgent research into novel and efficient therapies. In the current research, we have designed pyridine substituted pyrazole 1,3,5-triazine derivatives as antimalarials. A library including 300 compounds, designated as 7S (1-300), has been generated using a variety of aliphatic and aromatic amines. Ten compounds have been selected via in silico screening such as molecular properties, toxicity study, docking study and conventional synthesis for antimalarial evaluation against P. falciparum strains 3D7 (chloroquine-sensitive) and Dd2 (chloroquine-resistant). The docking results of compounds 7s258 and 7s5 revealed higher binding

SUBMITTER: Devanath B 

PROVIDER: S-EPMC11568084 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature