Survival prediction in patients with head and neck squamous cell carcinoma and novel mechanistic insights of S100A8/A9.

ABSTRACT:

Background

S100A8/A9, an innate immune protein, significantly regulates inflammatory processes and immune responses. While S100A8/A9 has been linked to various diseases, its association with head and neck squamous cell carcinoma (HNSCC) remains unclear.

Methods

Samples from the Cancer Genome Atlas (TCGA) were categorized into groups with low and high expression of S100A8/A9. R software, Sangerbox, UALCAN, GEPIA2, STRING, Cytoscape, TCGC Data Portal, miRcode, OncomiR and ENCORI databases were used to comprehensively study the expression, interactome and mutational profiles of S100A8/A9 and associated mechanism in HNSCC.

Results

The proteins S100A8/A9 were found to be associated with processes of 'epithelium development', 'regulating pluripotency of stem cells' and 'reg

SUBMITTER: Hu Y 

PROVIDER: S-EPMC11568106 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature