Cannabinoid regulation of angiotensin II-induced calcium signaling in striatal neurons.

ABSTRACT: Calcium ion (Ca²⁺) homeostasis is crucial for neuron function and neurotransmission. This study focused on the actions mediated by the CB₁ receptor (CB₁R), the most abundant G protein-coupled receptor (GPCR) in central nervous system (CNS) neurons, over by the AT₁R, which is one of the few G protein-coupled CNS receptors able to regulate cytoplasmic Ca²⁺ levels. A functional interaction suggesting a direct association between these receptors was detected. AT₁-CB₁ receptor heteromers (AT₁CB₁Hets) were identified in HEK-293T cells by bioluminescence resonance energy transfer (BRET²). Functional interactions within the AT₁-CB₁ complex and their potential relevanc

SUBMITTER: Rivas-Santisteban R 

PROVIDER: S-EPMC11568119 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature