Psychotropic-induced weight gain and telomere length: results from a one-year longitudinal study and a large population-based cohort.

ABSTRACT: Weight-inducing psychotropic treatments are risk factors for age-related diseases such as cardiovascular disorders, which are associated with both inflammation and telomere length shortening. With a longitudinal design, the present study evaluates telomere length trajectories after 1 year of weight-inducing psychotropic medication, accounting for weight changes and the inflammatory biomarker high-sensitivity C-Reactive Protein (CRP). Among 200 patients, an overall median telomere shortening of -41.2 bp was observed (p = 0.014), which is comparable with the general population's yearly telomere attrition. Linear regression showed on average -93.1 and -58.9 bp of further telomere shortening per five units of BMI for BMI values < or ≥30 kg/m², respectively (p = 0.003 and p = 0.009,

SUBMITTER: Piras M 

PROVIDER: S-EPMC11568132 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature