Comprehensive assessment of cellular senescence in intestinal immunity and biologic therapy response in ulcerative colitis.

ABSTRACT: Ulcerative Colitis (UC) is an inflammatory disorder characterized by chronic intestinal inflammation and immune dysregulation. Despite a clear association between cellular senescence and chronic inflammation and immune dysregulation, the mechanisms underlying cellular senescence in UC remain unclear. We screened differentially expressed genes (DEGs) associated with cellular senescence in multiple UC datasets, performed immune infiltration analysis, and constructed clinical diagnostic models. Additionally, we investigated the relationship between key genes related to cellular senescence and disease remission in UC patients undergoing biologic therapy, validating their expression in a single-cell dataset. We identified six DEGs associated with cellular senescence (TWIST1, IGFBP5, MME, IFNG,

SUBMITTER: Yao B 

PROVIDER: S-EPMC11568168 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature