Age-dependent cerebral vasodilation induced by volatile anesthetics is mediated by NG2⁺ vascular mural cells.

ABSTRACT: Anesthesia can influence cerebral blood flow by altering vessel diameter. Using in vivo two-photon imaging, we examined the effects of volatile anesthetics, sevoflurane and isoflurane, on vessel diameter in young and adult mice. Our results show that these anesthetics induce robust dilation of cortical arterioles and arteriole-proximate capillaries in adult mice, with milder effects in juveniles and no dilation in infants. This anesthesia-induced vasodilation correlates with decreased cytosolic Ca²⁺ levels in NG2⁺ vascular mural cells. Optogenetic manipulation of these cells bidirectionally regulates vessel diameter, and their ablation abolishes the vasodilatory response to anesthetics. In immature brains, NG2⁺ mural cells are fewer in number and express lo

SUBMITTER: Zhou H 

PROVIDER: S-EPMC11568297 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature