Meta-analyses of epigenetic age acceleration and GrimAge components of schizophrenia or first-episode psychosis.

ABSTRACT: Schizophrenia is a common chronic psychiatric disorder that causes age-related dysfunction. The life expectancy in patients with schizophrenia is ≥10 years shorter than that in the general population because of the higher risk of other diseases, such as cardiovascular diseases. Aging studies based on DNA methylation status have received considerable attention. Several epigenetic age accelerations and predicted values of aging-related proteins (GrimAge and GrimAge2 components) have been analyzed in multiple diseases. However, no studies have investigated up to GrimAge and GrimAge2 components between patients with schizophrenia and controls. Therefore, we aimed to conduct multiple regression analyses to investigate the association between schizophrenia and epigenetic age accelerations and Gr

SUBMITTER: Shirai T 

PROVIDER: S-EPMC11568310 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature