Membrane-bound receptor for advanced glycation end products (RAGE) is a stable biomarker of low-quality sperm.

ABSTRACT:

Study question

Does receptor for advanced glycation end products (RAGE) on the surface membrane of the sperm cell function as a biomarker of low-quality sperm?

Summary answer

Membrane-bound RAGE at a cellular level directly correlates with low sperm motility, high cell permeability, decreased mitochondrial function, DNA fragmentation, and higher levels of apoptosis.

What is known already

RAGE has previously been measured by ELISA in low-quality sperm in diabetic men and has been shown to correlate with DNA fragmentation (terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL) assay).

Study design size duration

Semen samples were recovered from 60 non-obese, non-diabetic and non-smoking subjects, washed with fresh media, and analysed directly or pu

SUBMITTER: Browning J 

PROVIDER: S-EPMC11568349 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature