Gut Microbiome in Human Melioidosis: Composition and Resistome Dynamics from Diagnosis to Discovery.

ABSTRACT:

Background

Melioidosis, attributable to the soil-dwelling bacterium Burkholderia pseudomallei, stands as a paramount global health challenge, necessitating extended courses of antibiotics. While murine studies identified the gut microbiota as a modulator of bacterial dissemination during melioidosis, the human intestinal microbiota during melioidosis remains uncharacterized. Here, we characterized gut microbiota composition and antimicrobial resistance (AMR) genes at diagnosis, during treatment, and postdischarge for melioidosis. We hypothesized that the gut microbiota of melioidosis patients would be extensively distorted.

Methods

In this prospective observational cohort, stool samples of patients with culture-confirmed melioidosis admitted to a tertiary care hospita

SUBMITTER: Chowdhury S 

PROVIDER: S-EPMC11568386 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature