Causality between autoimmune diseases and schizophrenia: a bidirectional Mendelian randomization study.

ABSTRACT:

Background

Observational studies have shown a link between autoimmune diseases and schizophrenia, with conflicting conclusions. Due to the existence of confounding factors, the causal link between autoimmune diseases and schizophrenia is still unknown.

Method

We conducted a comprehensive Mendelian randomization (MR) analysis of schizophrenia and ten common autoimmune diseases in individuals of European descent using genome-wide association studies (GWASs). To evaluate the relationships between autoimmune diseases and schizophrenia, inverse variance weighted, MR-RAPS, Bayesian weighted MR, constrained maximum likelihood, debiased IVW, MR-Egger, and weighted median were utilized. Several sensitivity analyses were performed to ensure the reliability of the study's results.

R

SUBMITTER: Duan L 

PROVIDER: S-EPMC11568594 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature