The mediatory role of androgens on sex differences in glucose homeostasis and incidence of type 2 diabetes: the KORA study.

ABSTRACT:

Background

Sex differences exist in type 2 diabetes (T2D), and androgens have been implicated in the etiology of T2D in a sex-specific manner. We therefore aimed to investigate whether androgens play a role in explaining sex differences in glucose homeostasis and incidence of T2D.

Methods

We used observational data from the German population-based KORA F4 study (n = 1975, mean age: 54 years, 41% women) and its follow-up examination KORA FF4 (median follow-up 6.5 years, n = 1412). T2D was determined through self-reporting and confirmed by contacting the physicians and/or reviewing the medical charts. Multivariable linear and logistic regression models were employed to explore associations. Mediation analyses were performed to assess direct effects (DE) and indirect effects (I

SUBMITTER: Raeisi-Dehkordi H 

PROVIDER: S-EPMC11568628 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature