Profiling genetically driven alternative splicing across the Indonesian archipelago.

ABSTRACT: One of the regulatory mechanisms influencing the functional capacity of genes is alternative splicing (AS). Previous studies exploring the splicing landscape of human tissues have shown that AS has contributed to human biology, especially in disease progression and the immune response. Nonetheless, this phenomenon remains poorly characterized across human populations, and it is unclear how genetic and environmental variation contribute to AS. Here, we examine a set of 115 Indonesian samples from three traditional island populations spanning the genetic ancestry cline that characterizes Island Southeast Asia. We conduct a global AS analysis between islands to ascertain the degree of functionally significant AS events and their consequences. Using an event-based statistical model, we detecte

SUBMITTER: Ibeh N 

PROVIDER: S-EPMC11568790 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature