Exposure to diesel-related particulate matter, cortisol stress responsivity, and depressive symptoms in adolescents.

ABSTRACT: Exposure to air pollution is associated with higher risk for psychopathology; however, the mechanisms underlying this association are not clear. Dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis in response to stress has been implicated in depression. Here, we estimated annual exposure to particulate matter (PM) from diesel emissions in 170 9- to 15-year-old adolescents (56 % female) using their residential addresses and data from nearby monitoring sites. We obtained salivary cortisol samples from participants while they completed a social stress task and calculated area under the curve with respect to ground (AUCg) and with respect to increase (AUCi) in order to assess cortisol responsivity during stress. Participants also reported on their depressive symptoms and sleep disturb

SUBMITTER: Uy JP 

PROVIDER: S-EPMC11568899 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature