Pan-cancer analysis of oncogenic role of CEP55 and experiment validation in clear cell renal cell carcinoma.

ABSTRACT: Immunotherapy has emerged as a vital component in the contemporary landscape of cancer treatment. Recent studies have indicated that CEP55 plays an oncogenic role; however, its specific mechanisms in promoting tumor proliferation and its potential value in prognosis and immunotherapy prediction across various cancers remain to be elucidated. CEP55 was significantly overexpressed in 22 cancer types compared with their adjacent normal tissues. Elevated CEP55 expression was positively correlated with younger onset age, worse tumor stage, lower response rate to the first treatment, lower tumor-free survival rate, and poorer overall survival (OS) and disease-free survival (DFS) prognosis in most cancers. Moreover, CEP55 expression was positively correlated with its binding and related genes, su

SUBMITTER: Zhou L 

PROVIDER: S-EPMC11569145 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature