Association of polygenic liabilities for schizophrenia and bipolar disorder with educational attainment and cognitive aging.

ABSTRACT: To elucidate the specific and shared genetic background of schizophrenia (SCZ) and bipolar disorder (BPD), this study explored the association of polygenic liabilities for SCZ and BPD with educational attainment and cognitive aging. Among 106,806 unrelated community participants from the Taiwan Biobank, we calculated the polygenic risk score (PRS) for SCZ (PRS_SCZ) and BPD (PRS_BPD), shared PRS between SCZ and BPD (PRS_SCZ+BPD), and SCZ-specific PRS (PRS_SCZvsBPD). Based on the sign-concordance of the susceptibility variants with SCZ/BPD, PRS_SCZ was split into PRS_{SCZ_concordant}/PRS_{SCZ_discordant}, and PRS_BPD was split into PRS_{BPD_concordant}/PRS_{BPD_discordant}. Ordinal logistic regression

SUBMITTER: Wu CS 

PROVIDER: S-EPMC11569198 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature