Optimal use of antithrombotic agents in recent small subcortical strokes accompanied by atrial fibrillation.

ABSTRACT:

Background

This study aimed to evaluate the efficacy and safety of anticoagulants (AC) and antiplatelets (APT) in patients with recent small subcortical infarctions (RSSI) and atrial fibrillation (AF).

Methods

We utilized a prospective multicenter stroke registry database to identify patients with RSSI with a concurrent diagnosis of AF. Propensity score matching analysis was used to balance baseline differences among the AC-only, APT-only, and their combination groups. The main outcomes of interest were time to occurrence of minor and major bleeding, stroke recurrence, and all-cause mortality. Adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for each outcome were calculated using the multivariable Cox proportional hazard regression analysis.

Results

Of

SUBMITTER: Lee M 

PROVIDER: S-EPMC11569447 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature