Safety and clinical outcomes of endovascular therapy versus medical management in late presentation of large ischemic stroke.

ABSTRACT:

Introduction

The benefit of endovascular therapy (EVT) among stroke patients with large ischemic core (ASPECTS 0-5) in the extended time window outside of trial settings remains unclear. We analyzed the effect of EVT among these stroke patients in real-world settings.

Patients and methods

The CT for Late Endovascular Reperfusion (CLEAR) study recruited patients from 66 centers in 10 countries between 01/2014 and 05/2022. The extended time-window was defined as 6-24 h from last-seen-well to treatment. The primary outcome was shift of the 3-month modified Rankin scale (mRS) score. Safety outcomes included symptomatic intracranial hemorrhage (sICH) and mortality. Outcomes were analyzed with ordinal and logistic regressions.

Results

Among 5098 screened patients, 2451 were

SUBMITTER: Mujanovic A 

PROVIDER: S-EPMC11569454 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature