Detecting the Tumor Prognostic Factors From the YTH Domain Family Through Integrative Pan-Cancer Analysis.

ABSTRACT:

Objectives

Emerging evidence suggests that N6-methyladenosine (m⁶A) methylation plays a critical role in cancers through various mechanisms. This work aims to reveal the essential role of m⁶A methylation "readers" in regulation of cancer prognosis at the pan-cancer level.

Methods

Herein, we focused on one special protein family of the "readers" of m⁶A methylation, YT521-B homology (YTH) domain family genes, which were observed to be frequently dysregulated in tumor tissues and closely associated with cancer prognosis. Then, a comprehensive analysis of modulation in cancer prognosis was conducted by integrating RNA sequencing (RNAseq) datasets of YTH family genes and clinical information at the pan-cancer level.

Results

YTH family genes

SUBMITTER: Zhu CY 

PROVIDER: S-EPMC11569503 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature