Disrupted emotion regulation and spontaneous neural activity in panic disorder: a resting-state fMRI study.

ABSTRACT:

Background

Emotional dysregulation, particularly unconscious catastrophic cognitions, plays a pivotal role in the genesis of panic disorder (PD). However, no studies have yet applied the percentage of amplitude fluctuation (PerAF) metric in resting-state functional magnetic resonance imaging to examine spontaneous neural functioning and its relation to catastrophic cognitions in PD.

Objectives

To explore the interplay between resting-state neural activity, functional connectivity (FC), and unconscious emotion regulation in individuals with PD.

Design

Cross-sectional study.

Methods

The study encompassed 51 participants, including 26 PD patients and 25 healthy individuals. The PerAF algorithm was employed to explore the local spontaneous neural activity in PD. Re

SUBMITTER: Wang HY 

PROVIDER: S-EPMC11569504 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature