Lipid control and stroke risk in atrial fibrillation patients treated with direct oral anticoagulants and statins.

ABSTRACT:

Introduction

The risk of ischemic stroke and intracerebral hemorrhage (ICH) with intensive lipid control by statins among patients with atrial fibrillation (AF) who require direct oral anticoagulants (DOAC) is unclear. We aimed to determine the risks of ischemic stroke and ICH in AF patients treated with DOAC and statins.

Patients and methods

In a population-based retrospective cohort study, we identified AF patients concurrently on DOAC and statins from 2015 to 2021 in Hong Kong. Primary outcome was ischemic stroke. Secondary outcomes were ICH and death. We correlated study outcomes with low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) as time-varying, continuous variables with restricted cubic spline. In secondary analyses, the r

SUBMITTER: Ip B 

PROVIDER: S-EPMC11569511 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature