Multicenter validation of synthetic FLAIR as a substitute for FLAIR sequence in acute ischemic stroke.

ABSTRACT:

Purpose

To evaluate performance of synthetic and real FLAIR for identifying early stroke in a multicenter cohort.

Methods

This retrospective study was conducted using DWI and FLAIR extracted from the Endovascular Treatment in Ischemic Stroke image registry (2017-2021). The database was partitioned into subsets according to MRI field strength and manufacturer, and randomly divided into training set (70%) used for model fine-tuning, validation set (15%), and test set (15%). In test set, five readers, blinded to FLAIR sequence type, assessed DWI-FLAIR mismatch using real and synthetic FLAIR. Interobserver agreement for DWI-FLAIR rating and concordance between synthetic and real FLAIR were evaluated with kappa statistics. Sensitivity and specificity for identification of ⩽4.5 h

SUBMITTER: Hamon G 

PROVIDER: S-EPMC11569530 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature