Validity of Mehrviru^® and Sacace^® in molecular detection of HPV: a latent class analysis.

ABSTRACT:

Background

Valid diagnostic tests for human papillomavirus (HPV) detection are crucial to identify individuals at high risk of cervical cancer. We assessed and compared the validity of Mehrviru HPV genotyping and Sacace (HPV Genotypes 14 Real-TM Quant) for molecular detection of 14 high-risk human papillomaviruses.

Methods

We used three HPV test results to identify HPV-positive individuals (14 high-risk genotypes) in a specialist gynecology clinic. The HPV test results were collected using Mehrviru^®, Sacace^®, and a third kit from the clinical diagnostic laboratory. We used Latent class analysis to determine the actual status of HPV infection in study participants. The sensitivity, specificity, positive and negative predictive values, positive and negati

SUBMITTER: Nowrozi H 

PROVIDER: S-EPMC11569601 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature