A link between systemic low-grade inflammation and frailty in older adults: clinical evidence from a nationwide population-based study.

ABSTRACT:

Background/aims

Despite the possible role of systemic low-grade inflammation on frailty, the majority of previous studies have focused solely on the phenotypic frailty with limited participant numbers, thereby weakening the evidence supporting the notion that circulating C-reactive protein (CRP) could be a potential frailty biomarker.

Methods

This study is a nationally representative, population-based, cross-sectional analysis from the Korea National Health and Nutrition Examination Survey, involving 5,359 participants aged 65 and older. We generated a deficit accumulation frailty index (FI) based on 38 items, encompassing physical, cognitive, psychological, and social status. Frailty was classified as non-frail (FI ≤ 0.15), pre-frail (0.15 < FI ≤ 0.25), or frail (FI > 0.25)

SUBMITTER: Kang MG 

PROVIDER: S-EPMC11569926 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature