Identification of late-stage tau accumulation using plasma phospho-tau217.

ABSTRACT:

Background

Blood-based disease staging across the Alzheimer's disease (AD) continuum holds the promise to identify individuals that profit from disease-modifying therapies. We set out to identify Braak V⁺ (Braak V and/or VI) tau PET-positive individuals within amyloid-β (Aβ)-positive individuals using plasma biomarkers.

Methods

In this cross-sectional study, we assessed 289 individuals from the TRIAD cohort and 306 individuals from the WRAP study across the AD continuum. The participants were evaluated by amyloid-PET with [¹⁸F]AZD4694 or [¹¹C]PiB and tau-PET with [¹⁸F]MK6240 and measured plasma levels included total tau, phospho-tau isoforms (pTau) pTau-181, pTau-217, pTau-231, and N-terminal tau (NTA-tau). We evaluated the perform

SUBMITTER: Woo MS 

PROVIDER: S-EPMC11570195 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature