Assessing sepsis-induced immunosuppression to predict positive blood cultures.

ABSTRACT:

Introduction

Bacteremia is a life-threatening condition that can progress to sepsis and septic shock, leading to significant mortality in the emergency department (ED). The standard diagnostic method, blood culture, is time-consuming and prone to false positives and false negatives. Although not widely accepted, several clinical and artificial intelligence-based algorithms have been recently developed to predict bacteremia. However, these strategies require further identification of new variables to improve their diagnostic accuracy. This study proposes a novel strategy to predict positive blood cultures by assessing sepsis-induced immunosuppression status through endotoxin tolerance assessment.

Methods

Optimal assay conditions have been explored and tested in sepsis-suspect

SUBMITTER: Hernandez-Jimenez E 

PROVIDER: S-EPMC11570276 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature