Immortalization of patient-derived lip cells for establishing 3D lip models.

ABSTRACT:

Introduction

The lips fulfill various critical physiological roles besides being viewed as a fundamental aesthetic feature contributing to the perception of health and beauty. Therefore, any lip injury, abnormality, or congenital malformation, such as cleft lip, needs special attention in order to restore proper lip function and aesthetics. To achieve this goal, a better understanding of the complex lip anatomy, function, and biology is required, which can only be provided by basic research endeavors. However, the current lack of clinically relevant human lip cells and three-dimensional in vitro lip models, capable of replacing ethically questionable animal experimentations, represents a significant limitation in this area of research.

Methods

To address these limitat

SUBMITTER: Mansour F 

PROVIDER: S-EPMC11570282 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature