Multiscale fiber remodeling in the infarcted left ventricle using a stress-based reorientation law.

ABSTRACT: The organization of myofibers and extra cellular matrix within the myocardium plays a significant role in defining cardiac function. When pathological events occur, such as myocardial infarction (MI), this organization can become disrupted, leading to degraded pumping performance. The current study proposes a multiscale finite element (FE) framework to determine realistic fiber distributions in the left ventricle (LV). This is achieved by implementing a stress-based fiber reorientation law, which seeks to align the fibers with local traction vectors, such that contractile force and load bearing capabilities are maximized. By utilizing the total stress (passive and active), both myofibers and collagen fibers are reoriented. Simulations are conducted to predict the baseline fiber configurati

SUBMITTER: Mehri M 

PROVIDER: S-EPMC11570337 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature