Precursors and Development of Geographic Atrophy with Autofluorescence Imaging: Age-Related Eye Disease Study 2 Report Number 18.

ABSTRACT:

Purpose

To describe the sequence of events leading to development of geographic atrophy (GA) in age-related macular degeneration with fundus autofluorescence (FAF) imaging.

Design

Post hoc analysis of FAF images from the Age-Related Eye Disease Study 2.

Participants

Fundus autofluorescence images of 120 eyes (109 patients) with incident GA and at least 2 years of preceding FAF images.

Methods

Images of incident GA were stacked and aligned over FAF images of preceding annual visits. The regions of retina where incident GA developed were assessed on prior years' FAF images. These regions, defined as precursor lesions, were classified into minimal change autofluorescence, predominant hypoautofluorescence (decreased autofluorescence), predominant hyperautofluoresce

SUBMITTER: Holmen IC 

PROVIDER: S-EPMC11570449 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature