Distinguishable topology of the task-evoked functional genome networks in HIV-1 reservoirs.

ABSTRACT: HIV-1 reservoirs display a heterogeneous nature, lodging both intact and defective proviruses. To deepen our understanding of such heterogeneous HIV-1 reservoirs and their functional implications, we integrated basic concepts of graph theory to characterize the composition of HIV-1 reservoirs. Our analysis revealed noticeable topological properties in networks, featuring immunologic signatures enriched by genes harboring intact and defective proviruses, when comparing antiretroviral therapy (ART)-treated HIV-1-infected individuals and elite controllers. The key variable, the rich factor, played a pivotal role in classifying distinct topological properties in networks. The host gene expression strengthened the accuracy of classification between elite controllers and ART-treated patients. Ma

SUBMITTER: Wisniewski J 

PROVIDER: S-EPMC11570469 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature