BFAST: joint dimension reduction and spatial clustering with Bayesian factor analysis for zero-inflated spatial transcriptomics data.

ABSTRACT: The development of spatially resolved transcriptomics (ST) technologies has made it possible to measure gene expression profiles coupled with cellular spatial context and assist biologists in comprehensively characterizing cellular phenotype heterogeneity and tissue microenvironment. Spatial clustering is vital for biological downstream analysis. However, due to high noise and dropout events, clustering spatial transcriptomics data poses numerous challenges due to the lack of effective algorithms. Here we develop a novel method, jointly performing dimension reduction and spatial clustering with Bayesian Factor Analysis for zero-inflated Spatial Transcriptomics data (BFAST). BFAST has showcased exceptional performance on simulation data and real spatial transcriptomics datasets, as proven b

SUBMITTER: Xu Y 

PROVIDER: S-EPMC11570543 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature