Occipital hypoperfusion and motor reserve in Parkinson's disease: an early-phase ¹⁸F-FP-CIT PET study.

ABSTRACT: Individual variability exists in parkinsonian motor symptoms despite a similar degree of nigrostriatal dopamine depletion in Parkinson's disease (PD), called motor reserve. We enrolled 397 patients newly diagnosed with PD who underwent dual-phase ¹⁸F-FP-CIT PET upon initial assessment. Individual motor reserve was estimated based on initial parkinsonian motor symptoms and striatal dopamine transporter availability using a residual model. Patients with low motor reserve (the lowest quartile group, n = 100) exhibited decreased uptake in the occipital region compared to those with high motor reserve (the highest quartile group, n = 100) on early-phase ¹⁸F-FP-CIT PET images. Patients with high motor reserve had a lower risk of conversion to dementia than the those with lo

SUBMITTER: Yoon YJ 

PROVIDER: S-EPMC11570606 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature