Nucleotide coordinated polymers, a ROS-based immunomodulatory antimicrobial, doubly kill <i>Pseudomonas aeruginosa</i> biofilms of implant infections.

ABSTRACT: Pseudomonas aeruginosa causes high morbidity and mortality in nosocomial infections, and newly approved antibiotics have been declining for decades. A green and universal deprotonation-driven strategy is used to screen the guanylic acid-metal ion coordination polymer nanoparticles (GMC), instead of the failure of binding occurs when specific metal ion participation. We find that the precise pH-dependent oxidase-like activity of GMC-2 orchestrates a duple symphony of immune modulation for Pseudomonas aeruginosa biofilm infections. Specifically, GMC-2-mediated reactive oxygen species (ROS) regulation triggers mitochondrial dysfunction and releases damage-associated molecular patterns, engaging pattern recognition receptors and resulting in endogenous innate immune activation. M

SUBMITTER: Chen J 

PROVIDER: S-EPMC11570693 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature