Colistin-niclosamide effervescent dry suspension combats colistin-resistant Salmonella in vitro and in vivo.

ABSTRACT: The increasing incidence of bacterial infections caused by multidrug-resistant (MDR) Gram-negative bacteria has deepened the need for new effective treatments. It has been reported that niclosamide (NIC) can restore the sensitivity of Gram-negative bacteria to colistin (COL). However, NIC is practically insoluble in water and sparingly soluble in organic solvents, leading to limited therapeutic applications. This study aims to prepare a COL-NIC effervescent dry suspension (CNEDS) and evaluate its antibacterial effect against COL-resistant Salmonella both in vitro and in broiler chickens. With the sedimentation volume ratio as an index, suitable suspending agent, wetting agent, filler and effervescent agent were screened through a single-factor method. The preparation conditions were optimi

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11570728 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature