High-performance silk/polylactic acid composite scaffold material with immunomodulation and osteogenesis function.

ABSTRACT: The choice of suitable materials and effective structural design are crucial in influencing the therapeutic outcomes of bone tissue engineering scaffolds. This study introduces a controllable biodegradable composite scaffold composed of flat silkworm cocoon (FSC) and polylactic acid (PLA) as an innovative strategy for promoting bone healing in complex injuries. We focused on optimizing the scaffold's structural design, mechanical properties, and underlying mechanisms of osteogenesis. Initial experiments established the parameters for hot pressing the FSC, followed by mechanical performance tests to identify the optimal preparation conditions. Composite scaffolds incorporating PLA films were subsequently fabricated using these optimized parameters. The results indicate that the FSC/PLA comp

SUBMITTER: Rui J 

PROVIDER: S-EPMC11570744 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature