Cortical morphological alterations in adolescents with major depression and non-suicidal self-injury.

ABSTRACT:

Background

Non-suicidal self-injury (NSSI) involves repetitive self-harm without suicidal intent and is common among adolescents, often linked to major depressive disorder (MDD). NSSI can lead to physical harm, cognitive impairments, interpersonal issues, violent behavior, and increased risks of psychological disorders and suicide attempts later in life.

Methods

Voxel-based morphometry (VBM) and surface-based morphometry (SBM) were performed on 44 NSSI patients and 44 healthy controls (HCs). Differences in GMV, CT, and cortical complexity were compared using the two-sample t-tests and correlated with neuropsychological scales.

Results

NSSI patients exhibited significant GMV atrophy in multiple regions, including the left insula, left anterior cingulate cortex, left pu

SUBMITTER: Pang X 

PROVIDER: S-EPMC11570753 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature