Local TSH/TSHR signaling promotes CD8⁺ T cell exhaustion and immune evasion in colorectal carcinoma.

ABSTRACT:

Background

Dysfunction of CD8⁺ T cells in the tumor microenvironment (TME) contributes to tumor immune escape and immunotherapy tolerance. The effects of hormones such as leptin, steroid hormones, and glucocorticoids on T cell function have been reported previously. However, the mechanism underlying thyroid-stimulating hormone (TSH)/thyroid-stimulating hormone receptor (TSHR) signaling in CD8⁺ T cell exhaustion and tumor immune evasion remain poorly understood. This study was aimed at investigating the effects of TSH/TSHR signaling on the function of CD8⁺ T cells and immune evasion in colorectal cancer (CRC).

Methods

TSHR expression levels in CD8⁺ T cells were assessed with immunofluorescence and flow cytometry. Functional investig

SUBMITTER: Zeng S 

PROVIDER: S-EPMC11570765 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature