Ancestry-independent risk of venous thromboembolism in individuals with sickle cell trait vs factor V Leiden.

ABSTRACT:

Abstract

Sickle cell trait (SCT) is a risk factor for venous thromboembolism (VTE). Prior studies investigating the association between SCT and VTE have been performed nearly exclusively in Black populations. However, race-based research can contribute to systemic racism in medicine. We leveraged data from the 23andMe research cohort (4 184 082 participants) to calculate the ancestry-independent risk of VTE associated with SCT as well as comparative risk estimates for heterozygous factor V Leiden (FVL). Odds ratios (ORs) were calculated using a meta-analysis of 3 genetic ancestry groups (European [n = 3 183 142], Latine [n = 597 539], and African [n = 202 281]) and a secondary full-cohort analysis including 2 additional groups (East Asian [n = 159 863] and South Asian [n = 41 257])

SUBMITTER: Lin KH 

PROVIDER: S-EPMC11570785 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature