Mendelian randomization studies of lifestyle-related risk factors for stroke: a systematic review and meta-analysis.

ABSTRACT:

Objective

Stroke risk factors often exert long-term effects, and Mendelian randomization (MR) offers significant advantages over traditional observational studies in evaluating the causal impact of these factors on stroke. This study aims to consolidate and evaluate the relationships between potential causal factors and stroke risk, drawing upon existing MR research.

Methods

A comprehensive search for MR studies related to stroke was conducted up to August 2023 using databases such as PubMed, Web of Science, Embase, and Scopus. This meta-analysis examines the relationships between potential causative factors and stroke risk. Both random-effects and fixed-effects models were utilized to compile the dominance ratios of various causative elements linked to stroke. The reliabili

SUBMITTER: Tian Y 

PROVIDER: S-EPMC11570884 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature