Comparing robust proton versus online adaptive photon radiotherapy for short-course treatment of rectal cancer.

ABSTRACT:

Background and purpose

Image-guided proton beam therapy (IG-PBT) and cone-beam CT (CBCT)-based online adaptive photon radiotherapy (oART) have potentials to restrict radiation toxicity. They are both hypothesised to reduce therapy limiting bowel toxicity in the multimodality treatment of locally advanced rectal cancer (LARC). This study aimed to quantify the difference in relevant dose-volume metrics for these modalities.

Material and methods

Six-degrees-of-freedom IG-PBT and oART short-course radiotherapy (SCRT) were simulated for 18 LARC patients. Relative biological effectiveness (RBE) was 1.1 for IG-PBT. Delivered dose was evaluated using post-CBCTs. Target coverage was considered robust if average dose to 99% of the clinical target volume was ≥ 95% of the prescription.

SUBMITTER: Hundvin JA 

PROVIDER: S-EPMC11570970 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature