Perplexing paradoxical reactions: navigating the complexity of protracted tuberculosis meningitis-a case report.

ABSTRACT: Tuberculous meningitis (TBM) has considerable mortality and morbidity, and it often presents therapeutic challenges when complicated by paradoxical reactions (PRs). Here, the clinical course of four cases of TBM patients complicated by PRs in a longitudinal TB cohort is described while also providing insights from the larger clinical cohort. Research flow cytometry, biomarker analysis, and drug concentrations were performed on available samples. All participants were initiated on standard antituberculosis therapy (ATT) and enrolled at the onset of PRs (PR group) or 2-4 months after the start of ATT (controls). The four TBM participants highlighted here presented with fevers, headaches, neurological deficits, and fatigue at the initial presentation. Upon diagnosis, all were initiated on rif

SUBMITTER: Gooding MS 

PROVIDER: S-EPMC11570994 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature