Kidney Outcomes in Transthyretin Amyloid Cardiomyopathy.

ABSTRACT:

Importance

Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive cardiomyopathy that commonly presents with concomitant chronic kidney disease. Chronic kidney dysfunction is associated with worse outcomes, but the prognostic value of changes in kidney function over time has yet to be defined.

Objective

To assess the prognostic importance of a decline in estimated glomerular filtration rate (eGFR) in a large cohort of patients with ATTR-CM.

Design, setting, and participants

This retrospective, observational, single-center cohort study evaluated patients diagnosed with ATTR-CM at the National Amyloidosis Centre (NAC) in the UK who underwent an eGFR baseline assessment and a follow-up assessment at 1 year between January 2000 and April 2024. Data analysis was p

SUBMITTER: Ioannou A 

PROVIDER: S-EPMC11571068 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature