Circulating collagen breakdown products as a biomarker for presence and instability of human intracranial aneurysms.

ABSTRACT:

Introduction

There is an unmet need for improved detection of intracranial aneurysms (IAs) and distinction between stable and unstable (high rupture risk) IAs. Within the IA wall, synthesis and degradation of type I collagen as the main molecular constituent balance each other to maintain IA stability. We hypothesized that collagen breakdown products could serve as molecular markers for IA presence and instability.

Patients and methods

This prospective, cross-sectional, single-center study included patients with unstable (growing/symptomatic/ruptured) and stable IAs and controls. We determined C-telopeptide (CTx) and c-terminal telopeptide (ICTP) as breakdown products of type I collagen in arterial and venous blood.

Results

We included 107 participants with IAs (52 st

SUBMITTER: Hackenberg KA 

PROVIDER: S-EPMC11571164 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature