Hyperpolarized ¹³C and ³¹P MRS detects differences in cardiac energetics, metabolism, and function in obesity, and responses following treatment.

ABSTRACT: Obesity is associated with important changes in cardiac energetics and function, and an increased risk of adverse cardiovascular outcomes. Multi-nuclear MRS and MRI techniques have the potential to provide a comprehensive non-invasive assessment of cardiac metabolic perturbation in obesity. A rat model of obesity was created by high-fat diet feeding. This model was characterized using in vivo hyperpolarized [1-¹³C]pyruvate and [2-¹³C]pyruvate MRS, echocardiography and perfused heart ³¹P MRS. Two groups of obese rats were subsequently treated with either caloric restriction or the glucagon-like peptide-1 analogue/agonist liraglutide, prior to reassessment. The model recapitulated cardiovascular consequences of human obesity, including mild left ventricular h

SUBMITTER: Lewis AJM 

PROVIDER: S-EPMC11571269 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature