Automated Insulin Delivery in Adults With Type 1 Diabetes and Suboptimal HbA_1c During Prior Use of Insulin Pump and Continuous Glucose Monitoring: A Randomized Controlled Trial.

ABSTRACT:

Background

Automated insulin delivery (AID) systems offer promise in improving glycemic outcomes for individuals with type 1 diabetes. However, data on those who struggle with suboptimal glycemic levels despite insulin pump and continuous glucose monitoring (CGM) are limited. We conducted a randomized controlled trial to assess the effects of an AID system in this population.

Methods

Participants with hemoglobin A_1c (HbA_1c) ≥ 58 mmol/mol (7.5%) were allocated 1:1 to 14 weeks of treatment with the MiniMed 780G system (AID) or continuation of usual care (UC). The primary endpoint was change in time in range (TIR: 3·9-10·0 mmol/L) from baseline to week 14. After this trial period, the UC group switched to AID treatment while the AID group continued using t

SUBMITTER: Christensen MB 

PROVIDER: S-EPMC11571454 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature