Do Metrics of Temporal Glycemic Variability Reveal Abnormal Glucose Rates of Change in Type 1 Diabetes?

ABSTRACT:

Background

We aimed to identify the normal range of glucose rates of change (RoC) observed in health and assess whether existing metrics of temporal glycemic variability (GV-timing), such as mean absolute glucose change (MAG) and continuous overlapping net glycemic action (CONGA), are predictive of abnormally rapid RoC in type 1 diabetes (T1D).

Methods

We identified the normal range of RoC over one-hour intervals from continuous glucose monitoring (CGM) data of healthy individuals. Rapidly rising glucose was defined as RoC values above percentiles 99% (level 1, L1) or 99.9% (level 2, L2), and rapidly falling glucose as below 1% (L1) or 0.1% (L2). The percentage of time these thresholds are exceeded in a given individual is referred to as time in fluctuation (TIF). In a separ

SUBMITTER: Richardson R 

PROVIDER: S-EPMC11571577 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature