Mutated LRRK2 induces a reactive phenotype and alters migration in human iPSC-derived pericyte-like cells.

ABSTRACT:

Background

Pericytes play a crucial role in controlling inflammation and vascular functions in the central nervous system, which are disrupted in Parkinson's disease (PD). Still, there is a lack of studies on the impact of pericytes on neurodegenerative diseases, and their involvement in the pathology of PD is unclear. Our objective was to investigate the molecular and functional differences between healthy pericytes and pericytes with the LRRK2 G2019S mutation, which is one of the most common mutations associated with PD.

Methods

Our study employed pericyte-like cells obtained from induced pluripotent stem cells produced from PD patients with the LRRK2 G2019S mutation as well as from healthy individuals. We examined the gene expression profiles of the cells and analyzed how

SUBMITTER: Peltonen S 

PROVIDER: S-EPMC11571670 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature