Impact of diabetes mellitus on the risk of Alzheimer's disease: a mendelian randomization study.

ABSTRACT:

Background

The impact of diabetes on the risk of Alzheimer's disease remains uncertain. This study aimed to explore this issue from multiple perspectives by using the Mendelian randomization (MR) approach.

Methods

Instrumental variables for predicting six diabetic traits (including insulin and blood glucose), eight metabolic risk factors for diabetes (including total cholesterol and blood pressure), and seven diabetic genes were extracted from their summary data. These data were derived from multiple European cohorts and included 31,684 to 810,865 subjects respectively. The two-sample MR, multivariate MR, and summary-data-based Mendelian randomization (SMR) methods were employed to determine the associations of these traits or genes with the risk of Alzheimer's disease.

R

SUBMITTER: Wang W 

PROVIDER: S-EPMC11571773 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature