QGO: a novel method for quantifying the diversity of mitochondrial genome organization.

ABSTRACT: Quantifying the features of mitochondrial genome structural variation is crucial for understanding its contribution to complexity. Accurate quantification and interpretation of organizational diversity can help uncover biological evolutionary laws and patterns. The current qMGR approach accumulates the changes in two adjacent genes to calculate the rearrangement frequency RF of each single gene and the rearrangement score RS for specific taxa in the mitogenomes of a given taxonomic group. However, it may introduce bias, as it assigns scores to adjacent genes rather than to rearranged genes. To overcome this limitation, we propose a novel statistical method called qGO to quantify the diversity of gene organization. The qGO method, which is based on the homology of gene order, provides a mor

SUBMITTER: Shi H 

PROVIDER: S-EPMC11571882 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature